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Exceptional Antibodies to Elusive Targets.  Scientific image.

Antibody Discovery Platform

Jennifer D. Könitzer, Shreya Pramanick, Qi Pan, Robert Augustin, Sebastian Bandholtz, William Harriman & Shelly Izquierdo (2017). Generation of a highly diverse panel of antagonistic chicken monoclonal antibodies against the GIP receptor. mAbs, 1-14.

Mettler Izquierdo S, Varela S, Park M,  Collarini E, Lu D, Pramanick S, Rucker J, Lopalco L, Etches R & Harriman W (2016). High-efficiency antibody discovery achieved with multiplexed microscopy (2016).  Microscopy.

Abdiche YN, Harriman R, Deng X, Yeung YA, Miles A, Morishige W, Boustany L, Zhu L, Mettler-Izquierdo S & Harriman W (2015). Assessing kinetic and epitopic diversity across orthogonal monoclonal antibody generation platforms. mAbs, 264-277.

Leighton PA, Schusser B, Yi H, Glanville J & Harriman W (2015). A diverse repertoire of human immunoglobulin variable genes in a chicken B cell line is generated by both gene conversion and somatic hypermutation. Frontiers in Immunology 6, 126.

Schusser B, Yi H, Collarini EJ, Izquierdo SM, Harriman WD, Etches RJ, Leighton PA, (2013). Harnessing gene conversion in chicken B cells to create a human antibody sequence repertoire. PLoS ONE 8, e80108.

Avian Engineering

Dimitrov L, Pedersen D, Ching KH, Yi H, Collarini EJ, Izquierdo S, Van De Lavoir M-C, Leighton PA (2016). Germline Gene Editing in Chickens by Efficient CRISPR-Mediated Homologous Recombination in Primordial Germ Cells. PLoS ONE, 11(4), e0154303.

Leighton PA, Pedersen D, Ching K, Collarini EJ., Izquierdo S, Jacob R, & Van De Lavoir M-C (2016). Generation of chickens expressing Cre recombinase. Transgenic Research, 1–8.

Collarini E, Leighton P, Pedersen D, Harriman B, Jacob R, Mettler-Izquierdo S, Yi H, Van De Lavoir M-C & Etches RJ (2015). Inserting random and site-specific changes into the genome of chickens. Poultry Science, 94(4), 799–803.

Song Y, Duraisamy S, Ali J, Kizhakkayil J, Jacob VD, Mohammed MA, Eltigani MA, Amisetty S, Shukla MK, Etches RJ & van de Lavoir M-C. (2014). Characteristics of Long-Term Cultures of Avian Primordial Germ Cells and Gonocytes. Biology of Reproduction  90(15), 1–8.

Schusser B, Collarini EJ, Yi H, Izquierdo SM, Fesler J, Pedersen D, Klasing KC, Kaspers B, Harriman WD, van de Lavoir M-C, Etches RJ & Leighton PA (2013). Immunoglobulin knockout chickens via efficient homologous recombination in primordial germ cells. PNAS 110(50), 20170–20175.

van de Lavoir M-C, Collarini EJ, Leighton, PA, Fesler J, Lu DR, Harriman WD, Thiyagasundaram TS & Etches RJ  (2012). Interspecific Germline Transmission of Cultured Primordial Germ Cells. PLoS ONE, 7(5), e35664.

Leighton PA, van de Lavoir M-C, Diamond JH, Xia C and Etches RJ (2008). Genetic modification of primordial germ cells by gene trapping, gene targeting, and C31 integrase. Molecular Reproduction Development. 75:1163-1175.

van de Lavoir M-C, Diamond J, Leighton P, Mather-Love C, Heyer B, Hooi L, Kerchner A, Gessaro T, Swanberg SE, Delany ME, Etches RJ (2006). Germline transmission of genetically modified primordial germ cells. Nature, 441:766-769.