Company Logo
Exceptional Antibodies to Elusive Targets.  Scientific image.

Antibody Discovery Platform

Jennifer D. Könitzer, Shreya Pramanick, Qi Pan, Robert Augustin, Sebastian Bandholtz, William Harriman & Shelly Izquierdo (2017). Generation of a highly diverse panel of antagonistic chicken monoclonal antibodies against the GIP receptor. mAbs, 1-14.

http://tandfonline.com/doi/full/10.1080/19420862.2016.1276683

Mettler Izquierdo S, Varela S, Park M,  Collarini E, Lu D, Pramanick S, Rucker J, Lopalco L, Etches R & Harriman W (2016). High-efficiency antibody discovery achieved with multiplexed microscopy (2016).  Microscopy.

http://jmicro.oxfordjournals.org/content/early/2016/04/21/jmicro.dfw014.full.pdf

Abdiche YN, Harriman R, Deng X, Yeung YA, Miles A, Morishige W, Boustany L, Zhu L, Mettler-Izquierdo S & Harriman W (2015). Assessing kinetic and epitopic diversity across orthogonal monoclonal antibody generation platforms. mAbs, 264-277.

http://doi.org/10.1080/19420862.2015.1118596

Leighton PA, Schusser B, Yi H, Glanville J & Harriman W (2015). A diverse repertoire of human immunoglobulin variable genes in a chicken B cell line is generated by both gene conversion and somatic hypermutation. Frontiers in Immunology 6, 126.

http://dx.doi.org/10.3389/fimmu.2015.00126

Schusser B, Yi H, Collarini EJ, Izquierdo SM, Harriman WD, Etches RJ, Leighton PA, (2013). Harnessing gene conversion in chicken B cells to create a human antibody sequence repertoire. PLoS ONE 8, e80108.

http://doi.org/10.1371/journal.pone.0080108

Avian Engineering

Dimitrov L, Pedersen D, Ching KH, Yi H, Collarini EJ, Izquierdo S, Van De Lavoir M-C, Leighton PA (2016). Germline Gene Editing in Chickens by Efficient CRISPR-Mediated Homologous Recombination in Primordial Germ Cells. PLoS ONE, 11(4), e0154303.

http://doi.org/10.1371/journal.pone.0154303

Leighton PA, Pedersen D, Ching K, Collarini EJ., Izquierdo S, Jacob R, & Van De Lavoir M-C (2016). Generation of chickens expressing Cre recombinase. Transgenic Research, 1–8.

http://doi.org/10.1007/s11248-016-9952-6

Collarini E, Leighton P, Pedersen D, Harriman B, Jacob R, Mettler-Izquierdo S, Yi H, Van De Lavoir M-C & Etches RJ (2015). Inserting random and site-specific changes into the genome of chickens. Poultry Science, 94(4), 799–803.

http://doi.org/10.3382/ps.2014-04372

Song Y, Duraisamy S, Ali J, Kizhakkayil J, Jacob VD, Mohammed MA, Eltigani MA, Amisetty S, Shukla MK, Etches RJ & van de Lavoir M-C. (2014). Characteristics of Long-Term Cultures of Avian Primordial Germ Cells and Gonocytes. Biology of Reproduction  90(15), 1–8.

http://www.biolreprod.org/content/early/2013/12/05/biolreprod.113.113381

Schusser B, Collarini EJ, Yi H, Izquierdo SM, Fesler J, Pedersen D, Klasing KC, Kaspers B, Harriman WD, van de Lavoir M-C, Etches RJ & Leighton PA (2013). Immunoglobulin knockout chickens via efficient homologous recombination in primordial germ cells. PNAS 110(50), 20170–20175.

http://doi.org/10.1073/pnas.1317106110

van de Lavoir M-C, Collarini EJ, Leighton, PA, Fesler J, Lu DR, Harriman WD, Thiyagasundaram TS & Etches RJ  (2012). Interspecific Germline Transmission of Cultured Primordial Germ Cells. PLoS ONE, 7(5), e35664. 

http://doi.org/10.1371/journal.pone.0035664

Leighton PA, van de Lavoir M-C, Diamond JH, Xia C and Etches RJ (2008). Genetic modification of primordial germ cells by gene trapping, gene targeting, and C31 integrase. Molecular Reproduction Development. 75:1163-1175.

http://doi.org/10.1002/mrd.20859

van de Lavoir M-C, Diamond J, Leighton P, Mather-Love C, Heyer B, Hooi L, Kerchner A, Gessaro T, Swanberg SE, Delany ME, Etches RJ (2006). Germline transmission of genetically modified primordial germ cells. Nature, 441:766-769.

http://doi.org/10.1038/nature04831